Effect of Thyroxine on Early Development of Chick Limb Buds
نویسنده
چکیده
منابع مشابه
Cyclosporine Effects on Chick Limb Bud Mesenchyme and DNA Content
Background: Cyclosporine A (CsA) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. Many transplant recipients must take this medicine for the rest of their lives. Females in reproductive age group on prolonged CsA therapy have legitimate concerns about drug effects on pregnancy. Objective: To explore Cs...
متن کاملPlatelet-derived growth factor A modulates limb chondrogenesis both in vivo and in vitro
Cartilage formation in the chick limb follows rapid proliferation, condensation and differentiation of limb mesenchyme. The control of these early events is poorly understood. Platelet-derived growth factor receptor alpha (PDGFR-alpha) is present throughout the mesenchyme of early chick limb buds, while its ligand, PDGF-A, is expressed in the surrounding epithelium. PDGFR-alpha is down-regulate...
متن کاملExpression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds.
The Eph-related receptor tyrosine kinase gene, Cek-8, is expressed in mesenchyme at the tip of chick limb buds, with high levels of transcripts posteriorly and apically but fading out anteriorly. Expression of Cek-8 in distal mesenchyme is regulated by apical ridge- and FGF-polarising signals and retinoic acid, and is uniform across the anteroposterior axis in talpid3 mutants. These data indica...
متن کاملThe chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation.
In chick embryos homozygous for the limbless mutation, limb bud outgrowth is initiated, but a morphologically distinct apical ridge does not develop and limbs do not form. Here we report the results of an analysis of gene expression in limbless mutant limb buds. Fgf4, Fgf8, Bmp2 and Msx2, genes that are expressed in the apical ridge of normal limb buds, are not expressed in the mutant limb bud ...
متن کاملDistribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly.
A central feature of the tetrapod body plan is that two pairs of limbs develop at specific positions along the head-to-tail axis. However, the potential to form limbs in chick embryos is more widespread. This could have implications for understanding the basis of limb abnormalities. Here we extend the analysis to mouse embryos and examine systematically the potential of tissues in different reg...
متن کامل